In a first for the programme, Davina McCall and Nicky Campbell present an appeal for information on behalf of two families whose loved ones have been reported missing to the police. They look at the cases of Matthew Bone, who disappeared in March 2018, and Simon Greaves, who went missing five years ago. They also follow the story of Beryl Everall, who last saw her mother more than 60 years ago when she mysteriously disappeared from her life. All contact with her mother's side of the family was lost, and she was never spoken of again.