Armed with his Appleton's Guide, Michael Portillo travels the lower Mississippi aboard a paddle steamer to hear about the life and work of former river boat captain, Samuel Clemens, better known as Mark Twain. In the city of Memphis, Tennessee, Michael visits the historic Elmwood Cemetery, where he uncovers the story of a devastating epidemic, which claimed the lives of thousands. He discovers one of the largest rail freight hubs in the United States and in the home of the blues, meets contemporary artist Cedric Burnside in studio before joining millions of Elvis fans at Graceland. An invitation to a duck palace and the honorary position of Duck Master carry curious responsibilities at the 19th-century Peabody Hotel.