Suffering from intense headaches, Arch sends Macy home to rest, but after passing out and crashing her car accident, Macy is admitted to hospital. Macy is initially believed to be okay and just in need of rest, but following a seizure it is discovered that she has a brain aneurysm. After asking Marina to give her last rights, just in case, the aneurysm bursts and despite the frantic efforts of her colleagues, Macy passes away. Bree and Harry are wed while Wayne, after a leave of absence from the ER, decides to leave emergency medicine entirely.